Acetoacetate—CoA ligase
| acetoacetate-CoA ligase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 6.2.1.16 | ||||||
| CAS number | 39394-62-2 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, an acetoacetate-CoA ligase (EC 6.2.1.16) is an enzyme that catalyzes the chemical reaction
- ATP + acetoacetate + CoA
AMP + diphosphate + acetoacetyl-CoA
The 3 substrates of this enzyme are ATP, acetoacetate, and CoA, whereas its 3 products are AMP, diphosphate, and acetoacetyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acetoacetate:CoA ligase (AMP-forming). This enzyme is also called acetoacetyl-CoA synthetase. This enzyme participates in butanoate metabolism.
References
- Fukui T, Ito M, Tomita K (1982). "Purification and characterization of acetoacetyl-CoA synthetase from Zoogloea ramigera I-16-M". Eur. J. Biochem. 127 (2): 423–8. doi:10.1111/j.1432-1033.1982.tb06889.x. PMID 7140777.